Adress: Oude Markt 13; 3000 Leuven

Activity: Higher or Secondary Education Establishments

Web site

KU Leuven is one of Europe’s highest-ranked and most renowned universities. It boasts a long tradition of pioneering research and high-quality education. As a leading research university and co-founder of the League of European Research Universities, KU Leuven accommodates all kinds of research, from fundamental to applied, from individual projects to participation in large-scale, prestigious international research consortia, such as the European Research Council and Horizon 2020

Laboratory of Immunobiology Carine Wouters and Patrick Matthys

The Laboratory of Immunobiology focuses its research on the pathogenic mechanisms that drive different autoimmune and autoinflammatory diseases, including rheumatoid arthritis, systemic juvenile idiopathic arthritis, and macrophage activation syndrome and hemophagocytic lymphohistiocytosis. The work performed always aims to provide translational insights, by combining findings in relevant animal models with data obtained on patient samples, comparing both active and inactive disease episodes. Prof. Dr. Carine Wouters works in the University Hospital of Leuven and is responsible for the treatment and recruitment of paediatric SAID patients and sample collection  (WP1). Prof.. Patrick Matthys is responsible for  in-depth analysis of NK cells from SAID patients before and after treatment, in comparison with healthy controls.

Laboratory of Molecular Immunology /Department of Microbiology and Immunology Paul Proost

The Laboratory of Molecular Immunology (Department of Microbiology and Immunology, KU Leuven) is embedded in the Rega Institute, a multi-departmental institute in which medicinal chemistry, microbiological and immunological research groups are combined. It is led by Prof. Paul Proost and has a strong background in protein biochemistry including chemical synthesis of intact (modified) chemokines, purification and identification of chemokines and evaluation of chemokine-receptor and chemokine-glycosaminoglycan interactions. In addition, they have major research lines on the function of chemokines in acute and chronic inflammation, autoimmunity and cancer. In ImmunAID, they will evaluate the presence of chemokine modifying enzymes in patient samples and quantify post-translationally modified chemokines (discriminating between chemokine forms with different biological activities) by western blot or nano scale UPLC coupled to mass spectrometry (MS/MS).

Adress: Norregade 10; 1165 Kobenhavn

Activity: Higher or Secondary Education Establishments

Web site

Københavns Universitet (www.ku.dk) is the largest university in Scandinavia and ranked among the top 50 universities in the world. With over 40,000 students and more than 9,000 employees, the University of Copenhagen is one of the largest institutions of research and education in the Nordic countries.

K. Belling                S. Brunack

The Novo Nordisk Foundation Center for Protein Research (CPR) is located at the University Of Copenhagen Medical School. It is organized into four major programs, where the Programme for Disease Systems Biology works as a multi-disciplinary basic research group within bioinformatics and systems biology with particular focus on large data sets of relevance to human health. The CPR has a highly multidisciplinary profile (molecular biologists, biochemists, medical doctors, physicists and computer scientists). The center conducts basic research and has been financed by a grant from the Novo Nordisk Foundation, with contributions from the university.

UCPH-CPR has general expertise in molecular level systems biology and healthcare data integration. It will be involved in WP6 in the analysis and integration of health data, in particular the steps in the WP6 regarding bioinformatics and data analysis. This will involve broad analysis of biomarkers, both omics-markers as well as more directed measurements, in an integrated fashion. To do so, machine-learning methods, statistical analyses and meta-tools will be developed and implemented.

Adress: 3 Avenue Victoria; 75004 Paris

Activity: Research Organisations

Web site

APHP.6, GH Pitié-Salpetrière and Tenon, Department of Internal Medicine and clinical immunology David Saadoun, B Fautrel, S Georgin-Lavialle

B. Fautrel                S. Georgin-Lavialle

Internal Medicine and Clinical Immunology Department of GH la Pitié-Salpêtrière has a National and international recognized expertise in the care of adult patients suffering of auto-immune/inflammatory (AIS) rare diseases and is a leading member of the National Reference Center for Rare Systemic and Auto-Immune Diseases. Pr David Saadoun is recruiting patients for ImmunAID cohort and is a WP5 task leader on dosage of cytokine, chemokine, adipokine and mast cells mediators in SAIDs patients’ samples.

Hôpital Saint-Louis – Dermatology Department Jean David Bouaziz

Dermatology Department, Saint Louis hospital, Paris, France is a large unit including inpatients and outpatients with inflammatory skin diseases (neutrophilic dermatosis and auto-immune disorders), infectious skin diseases and dermato-oncology. The skin research center, INSERMU976 in  Saint Louis hospital, Paris, France has  great area expertise in skin inflammatory diseases, T cell and B cell population.. Pr JD Bouaziz is involved in WP1 as one of the leader of the neutrophilic dermatosis part of the project.

Kremlin-Bicêtre Hospital - The Paediatric rheumatology department, Isabelle Kone Paut

The is the main university hospital in South of Paris area. The Paediatric rheumatology department

The paediatric rheumatology department of the University Hospital of Bicêtre deals with significant number of patients and families in all fields of paediatric inflammatory diseases. Of note it cares the widest population of paediatric patients with FMF, PFAPA, Behcet's disease, CRMO and CAPS in France. It is also a  a EULAR center of excellence for rheumatology 2015-2020, a member of the ERN RITA, and the HCP has been designated autoinflammatory diseases representative within the steering committee of this ERN; the national reference center for rare autoinflammatory disorders: CEREMAIA ; and connected with two INSERM research units: INSERM U 1018; Centre de recherche en Epidémiologie et Santé des Population (CESP) and INSERM U1183 "Cellules souches, plasticité cellulaire, médecine régénératrice et immunothérapies"). Isabelle Koné-Paut is participating to the coordintation of ImmunAId cohort and will recruit patients.

Institut Curie

Adress: Schlossplatz 2; 48149 Muenster

Activity: Higher or Secondary Education Establishments

Web site

With more than 44,500 students, the University of Münster is one of the largest universities in Germany and has developed a strong research profile in natural sciences, humanities, medicine, law and business administration. It targets top-level research in high-performance areas for support and combines this with promoting first-class junior research staff.

C . Kessel               D. Foell

The Department of Paediatric Rheumatology and Immunology led by Prof. Dr. Dirk Foell, as a center for auto inflammatory diseases in childhood, is including patients and collecting biological samples of high quality in ImmunAID cohort. Pr D. FOell is also leading WP5 and his team is in charge of delineating Delineating potential cross-talk between neutrophils and neutrophil products with monocytes, macrophages and T cells.

Adress: Soranou Efesiou 4; 115 27 Athina

Activity: Research Organisations

Web site

Established in 2003, the Biomedical Research Foundation of the Academy of Athens (BRFAA) is already the largest biomedical research institution of Greece with 5 Research Centers, 400 research personnel (postdoctoral fellows, laboratory technicians and Ph.D. students) and 50 faculty members with a track record of scientific excellence coming from leading US and European Institutions

The Laboratory of Immunobiology of the centre for Translational and Clinical Research led by Dr Evangelos Andreakos has been established since 2006 and focuses on the study of the role of innate immunity in acute and chronic inflammation. Affiliated investigators to BRFAA from the University of Athens Medical School and the ‘Attikon’ and ‘Laikon’ University Hospitals (Prof. Boumpas, Prof. Tzioufas, and Prof. Sfikakis) give to BRFAA a strong translational direction.

In addition to patient recruitment the Laboratory of Immunology will study of the mechanisms of resolution of inflammation in SAID patients, unwinding of the molecular networks and pathways controlling SPM production and response.

Panepistimio Ioanninon (UOI)

Adress: Panepistemioypole Panepistemio Ioanninon; 45110 Ioannina

Activity: Higher or Secondary Education Establishments

Web site

The University of Ioannina ([http://www.uoi.gr/en]/) was founded in 1964 in Ioannina, Epirus, in the North-western part of Greece. Today, the University has 17 departments with over 500 faculty members, 13,500 undergraduate students and more than 3,000 graduate students (MSc and PhD). The University of Ioannina has established a quality management system that is in conformance with the International Management System Standard ISO 9001:2000, as well as the Greek Management Efficiency Standard, with a scope of “Project Management of Research and Development of Technological and Other Related Programs and Activities”.

  ExarchosTP          FotiadisDI              PapaloukasC       RigasG

The work in ImmunAID project will be undertaken by Prof. Fotiadis research unit, the Unit of Medical Technology & Intelligent Information Systems (MedLab). MedLab is a highly innovative and self-contained research unit strongly activated in the fields of Biomedical Engineering and development of Intelligent Information systems. MedLab’s research activities cover a variety of subjects and they are classified into the following domains: Biomedical Research, Automated Diagnosis - Processing and analysis of biomedical signals (e.g. ECG, EMG) and images (e.g. MRI, ultrasound), Bio magnetism and Biomaterials, Bioinformatics, Networks, Medical Informatics, Data mining, Applications of predictive data mining methodologies, especially in clinical domain. In ImmunAID MedLab’s will design decision-making algorithms, to integrate the use of novel classification in the form of simple algorithms/decision trees.

Adress: Piazza Sant Onofrio 4; 00165 Roma

Activity: Research Organisations

Web site

OPBG is a Scientific Institute for Research, Hospitalization and Health Care, Italy’s largest paediatric Hospital providing advanced health care for children and performing basic, clinical and translational research. The Hospital is part of the Italian National Healthcare System and is widely recognized as referral centre for all paediatrics specialties.

The division of Rheumatology and the Lab of ImmunoRheumatology headed by Pr Fabrizio de Benedetti provides care to all rheumatic diseases of children in an in-patient section and dedicated out-patient clinics.

The OPBG follows a large number of patients with systemic JIA and will be involved in the recruitment of patients and collection of biosamples for the ImmunAID cohort.

Adress: Zaloska Cesta 002; 1000 Ljubljana

Activity: Higher or Secondary Education Establishments

Web site

University Medical Centre Ljubljana (UMCL) is the largest and most research-intensive hospital in Slovenia. University Children’s Hospital Ljubljana (UCHL) is an integral part of the UMCL and is the largest center dedicated to improving children’s health in the country with a long history of clinical and research excellence serving as the national and regional tertiary referral center for paediatric patients from Central and South Eastern European countries.

Rheumatology and Clinical Immunology department of the UCHL provides comprehensive services for children with auto inflammatory and immune-mediated inflammatory diseases. It is the only tertiary care paediatric rheumatology center in Slovenia with approx. 2500 paediatric rheumatology clinic visits per year and is a selected core member of the European Reference Network RITA (“Rare immunological and auto-inflammatory diseases”) and Slovenian National Coordinating Center of the PRINTO network. UMCL will provide structured data and biosamples from a well characterized cohort of patients with systemic auto inflammatory diseases.

Adress: Paseo Sant Joan De Deu 2; 08950 Esplugues De Llobregat

Activity: Research Organisations

Web site

Hospital Sant Joan de Déu-Barcelona Children’s Hospital (HSJD) is one of the leading medical centers in Europe for childhood and adolescence and offers a comprehensive and multidisciplinary approach to health care from birth through 18 years of age. HSJD is a private not-for-profit center, working mainly for the National Health System offering the public contracted services. HSJD is accredited by the Spanish Ministry of Health as a reference center for all Spain in a wide range of specialties and conditions (e.g., orthopaedics’, neurology and neurosurgery, reconstructive surgery, ophthalmology).

J. Anton

As the paediatric center of the University of Barcelona, HSJD is associated with the Clinic Hospital being the best-known hospital alliance in Spain and one of the international references for highly specialized hospital care, teaching and research. Given the major focus on paediatric and child development research, the Institute of Paediatric Research Hospital Sant Joan de Déu (IRP-HSJD) was created in 2015 by an institutional agreement and scientific collaboration between the HSJD and with Fundació Sant Joan de Déu, the Institute of Biomedicine of the University of Barcelona (IBUB), the Institute of Neurosciences (IR3C) University of Barcelona (UB), and the Biomedical Engineering Research Centre (CREB) of the Polytechnic University of Catalonia (UPC). Jordi Antón is in charge of coordinating of Spanish clinical centers and recruiting SAID patients.

Adress: Rue Du General Dufour 24; 1211 Geneve

Activity: Higher or Secondary Education Establishments

Web site

Founded in 1559 by Jean Calvin, the University of Geneva (UNIGE) is Switzerland’s second largest university enjoying a strong international reputation, both for the quality of its research (it ranks among the top institutions among the League of European Research Universities) and the excellence of its education. This acclaim has been won in part due to its strong ties to many national and international Geneva-based organizations, such as the World Health Organization..

The Department of Internal Medicine of the University of Geneva includes different specialties. The activity of Prof. Gabay group focuses on the role of cytokines of the interleukin (IL)-1 family in the immune and inflammatory responses. In particular, the group studies are focusing on experimental models of arthritis and other inflammatory diseases.In ImmunAID it will be involved in the measurement of IL-1 and IL-18 in biological samples with access to a unique assay that measures the biologically active fraction of IL-18.

Additionally, Pr. Gabay entity includes a clinical setting with outpatient and inpatient units associated with a clinical laboratory and a basic science laboratory that will provide patients and biosample to ImmunAID cohort.

  FMF & AID Global Association (FMFandAID)

Adress: Hacettepe Universitesi Beytepe Kampusu Rektorluk Binasi; 06800 Cankaya Ankara

Activity: Higher or Secondary Education Establishments

Web site

Hacettepe University, as one of the leading universities in the country, keeps contributing to social development and universal values in the fields of science, technology and art. Hacettepe University is one of the referral center of the rare diseases in Turkey.

The Department of Internal Medicine will collect clinical data and biosamples from AOSD patients

University of Leeds (UNIVLEEDS)

Adress: Woodhouse Lane; Ls2 9jt Leeds

Activity: Higher or Secondary Education Establishments

Web site

The University of Leeds (UNIVLEEDS) is acclaimed world-wide for the quality of its teaching and research and continues to be ranked within the top 100 universities in the QS world rankings. It is one of the largest universities in the UK with over 30,000 students (over 7,000 post graduate students) and approximately 6,450 staff of 99 different nationalities, attached to 560 different undergraduate and 300 postgraduate degree programs. Leeds is also a leading member of the UK’s prestigious research intensive Russell Group universities. In particular, it is currently coordinating 23 H2020 projects, and is a partner in a further 26 successful H2020 projects.

Experimental Rheumatology group studies the molecular mechanisms of responses to biologics and the unfolded protein response (UPR) in the pathogenesis of Rheumatoid Arthritis. In ImmunAID the group will be in charge of the study of inflammasome function by leading WP3

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University College London (ULC)

Adress: Gower Street; Wc1e 6bt London

Activity: Higher or Secondary Education Establishments

Web site

UCL is one of the world’s leading multidisciplinary universities, with more than 11,000 staff and 38,000 students from 150 different countries. Founded in 1826 in the heart of London, UCL was the first university in England to welcome students of any religion and the first to welcome women on equal terms with men. UCL operate in a global context and is committed to excellence, innovation and the promotion of global understanding in all activities: research, teaching, learning, and enterprise and community engagement.

The National Amyloidosos center is a highly specialized center with an interested in systemic auto inflammatory disorders as well as Amyloidosis. It is part of the Division of Medicine of University College London and based within the Royal Free NHS London Foundation Trust Hospital.

Helen Lachmann will be in charge of the inclusion of patients with monogenetic auto inflammatory diseases, patients with Fever of unknown origin and patients with Adult Onset Stills disease.