INFLAMMATION OF UNKNOW ORIGIN
| Epidemiology | |||||
|---|---|---|---|---|---|
|
|
1:1 |
Average onset age |
16-35y |
Incidence |
1-100/106 |
Disease presentation
- Characterized by intense systemic inflammation with heterogeneous flare frequency
- Diagnosed by elimination of other causes (infection, autoimmunity, cancer)
Main clinical symptoms
Repeated hyperthermia for a few hours in the evening
Joint pain/swelling
Skin rash
Biological signs
Increase in white blood cell counts
Increase in ferritin
Decrease in glycosylated ferritin
Therapy
- Corticosteroids
- Non-steroidal anti-inflammatory drugs
- Anti-IL-1 (e.g. Anakinra, Canakinumab)
- Anti-IL-6 (e.g. Tocilizumab)
