INFLAMMATION OF UNKNOW ORIGIN

web inflammation unknown origin
Epidemiology

Light blue gender
Gender ratio

1:1

Light blue age

Average onset age

16-35y

Light blue incidence

Incidence

1-100/106

Disease presentation

  • Characterized by intense systemic inflammation with heterogeneous flare frequency
  • Diagnosed by elimination of other causes (infection, autoimmunity, cancer)

Main clinical symptoms

picto feverRepeated hyperthermia for a few hours in the evening

picto Joint painJoint pain/swelling

picto skin rashSkin rash

Biological signs

Light blue upIncrease in white blood cell counts

Light blue upIncrease in ferritin

Light blue downDecrease in glycosylated ferritin

Therapy

  • Corticosteroids
  • Non-steroidal anti-inflammatory drugs
  • Anti-IL-1 (e.g. Anakinra, Canakinumab)
  • Anti-IL-6 (e.g. Tocitizumab)