Disease presentation

Under diagnosed, the disease involves skin, joint and bone with potential complications associated with proliferation of lymphocytes. The diagnosis relies on combined clinical, biological and imaging components.

Main clinical symptoms

Transient skin rash (mild at first followed by red macules or plaques)

Elevated but well tolerated fever

Bone pain

Joint pain with possible lesions

Biological signs

Presence of monoclonal immunoglobulins (IgM)

Increase of erythrocyte sedimentation rate

Therapy

• Anti-IL-1 (Anakinra)