STILL DISEASE
Adult onset Still Disease
Epidemiology | |||||
---|---|---|---|---|---|
Gender ratio |
1 : 1 |
Average onset age |
16-35 y |
Incidence |
1/105 - 106 |
Disease presentation
The disease is characterized by intense systemic inflammation with heterogeneous flare frequency. It is usually diagnosed after the elimination of all other possible causes (infection, autoimmunity, cancer)
Main clinical symptoms
Repeated hyperthermia for a few hours in the evening
Joint pain/swelling
Skin rash
Biological signs
Increase in white blood cell counts
Increase in ferritin
Decrease in glycosylated ferritin
Therapy
- Corticosteroids
- Non-steroidal anti-inflammatory drugs
- Anti-IL-1 (e.g. Anakinra, Canakinumab)
- Anti-IL-6 (e.g. Tocitizumab)