FMF*

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Epidemiology

Purple gender

Gender ration

1 : 1

Purple incidence

Prevalence

1-5/104

Disease presentation

Genetic grounds

The disease shows an autosomal recessive inheritance (i.e., each parent must give a mutated gene for a child to develop the disease). The involved mutated gene is MEFV coding for pyrin involved in the pyrin inflammasome.

Main clinical symptoms

picto feverElevated fever with chills

picto Abdo painAbdominal pain

picto Joint painJoint pain

Biological signs

-

Therapy

  • Colchicin
  • Anti-IL-1 (e.g. Anakinra, Canakinumab)
  • Anti-IL-6 (e.g. Tocitizumab)

* Familial Mediterranean Fever