CHRONIC RECURRENT NON-BACTERIAL OSTEITIS

web Chronic recurrent

Epidemiology

SAPHO* Syndrome

Green gender

Gender ratio

 1+:1

Green age

Average onset age

30-40y

Green incidence

Incidence

 1/104

Chronic recurrent multifocal osteomyelitis (CRMO)

Green gender

Gender ratio

 2:1

Green age

Average onset age

10y

Green incidence

Incidence

 1-9/106

Disease presentation

The diseases are characterized by chronic osteitis with potentially transient or non-concomitant cutaneous symptoms. The diagnosis is supported by bone imaging and score algorithm.


Main clinical symptoms

picto Bone inflamBone/joint pain (spine, anterior chest wall, pelvis, knee, etc.)

picto skin rashSkin rash (acne & pustulosis on the palm of hands and under the soles of the feet)

picto feverFever

Biological signs

Inconclusive

Therapy

  • Non-steroidal anti-inflammatory drugs
  • Corticosteroids (prednisone)
  • Immunomodulating drugs (methotrexate)
  • anti-TNFα or bisphosphonate

*Synovitis - Acne - Pustulosis - Hyperostosis - Osteitis