NEWS and RESULTS of the Projet

The NLRP3 inflammasome is the most thoroughly studied of the inflammasomes, and represents a valuable target in the clinical evaluation and treatment of systemic autoinflammatory diseases (SAIDs). We’ve summarised the rapidly progressing field of NLRP3 inflammasome regulation and its wider implications, both in the laboratory and in the clinic.

The concept of autoinflammatory disorders was introduced by Daniel Kastner in 1999 (Michael McDermott was 1st author). Since then, characterization of these conditions has been continuously refined. After 20 years, McDermott, Caseley and Savic have advocated for a systems-based classification of the systemic autoinflammatory diseases (SAIDs) which defines the complex interplay of molecular mechanisms, and systems, at the heart of many monogenic and polygenic conditions.

Six centres are ready to enroll SAID patients in France. The opening of other French centres is foreseen in the coming weeks together with centres in other countries, such as Spain and Slovenia to start with. The real work begins!